Acathinol Memantine

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Acathinol is a drug that improves brain metabolism.The drug refers to nootropic and neuroprotective agents. The drug is taken with a decrease in memory and ability to concentrate, increased fatigue, craniocerebral trauma and a number of other diseases associated with impaired brain activity.

In international circles, the drug is called Acatinol Memantine. The drug belongs to the group of muscle relaxants, which affect the central nervous system.

On this page you will find all information about Acatinol Memantine: the full instructions for use on this medication, average prices in pharmacies, complete and incomplete analogs of the drug, as well as reviews of people who have already used Akatinol Memantine. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Blocker of glutamate NMDA-receptors. The drug used to treat dementia.

Conditions of leave from pharmacies

The drug is released by prescription.

Price list

How much does Acatinol Memantine cost? The average price in pharmacies is at the level of1 600 rubles.

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Form of release, composition and packaging

Drug Akatinol Memantine is produced in the form of tablets in the following secondary packages: 10 mg - No. 30 or No. 90; 20 mg - №28, №56 or №98. Also, one of the forms of release of the drug is a tabletset No. 28, comprising 7 tablets with different mass content of memantine (5 mg, 10 mg, 15 mg, 20 mg).

  • 1 tablet can include 5 mg / 10 mg / 15 mg or 20 mg memantine.

The additional composition of the substances in the tablet differs depending on the mass content of the active ingredient in it.

pharmachologic effect

The drug has an adverse effect. Acatinol is a therapeutic drug that is an antagonist of a noncompetitive type of NMDA (N-methyl-D-aspartate). The positive effect of memantine is due to its effect on glutamate NMDA receptors of the inotropic type. As a result, an effect of a modulating-type drug occurs, which has a direction on the glutamatergic type system.

Memantine takes an active part in the processes of regulating ion transport, improving the membrane potential, blocking the channels of the calcium type. When taking the medicine due to the effect being exerted, there is an improvement in the propagation of nerve impulses in the cerebral cortex brain, there is an increase in cognitive functioning of the brain and an increase in the daily activity of the patient.

At oral intake, a rapid and complete absorption of the drug is observed. The maximum level of plasma concentration of the drug occurs in the period from 2 to 6 hours. The half-life in the two phases of excretion is 4 to 9 hours in the first phase and from 40 to 65 hours in the second phase. The active component is excreted through the kidneys.

What helps the Akatinol Memantine?

The drug is administered to patients for treatment of the following pathologies:

  • Treatment of memory impairment and various psychosomatic disorders by type of Alzheimer's disease;
  • Vascular disorders that lead to memory impairment, concentration of attention, personality degradation;
  • Mixed dementia of varying severity.

Contraindications

Tablets Akatinol Memantine should be taken only as directed by a doctor. Before starting therapy, the patient should carefully study the accompanying instructions, since the drug has a number of the following contraindications:

  • Serious kidney disease with a violation of their function;
  • Pregnancy and the period of breastfeeding;
  • Age under 18 due to lack of clinical experience;
  • Individual intolerance to the components of the drug;
  • Congenital lactase insufficiency or malabsorption syndrome.

Relative contraindications are thyrotoxicosis, epilepsy, convulsive syndrome, myocardial infarction, heart failure.

Pregnancy

Akatinol Memantine is contraindicated in pregnancy and lactation (breastfeeding).

Instructions for Use Acatinol Memantine

In the instructions for use, it is indicated that Akatinol Memantine is ingested during meals. The dosage regimen is set individually. Begin the treatment recommended with the appointment of the minimum effective dose.

  • Adults with dementia syndrome are prescribed a drug during the first week of therapy at a dose of up to 5 mg / day, during the second week - at a dose of up to 10 mg / day, during the third week - 15-20 mg / day. If necessary, further weekly increase in the dose of 10 mg to achieve a daily dose of 30 mg.

The optimal dose is achieved gradually, with increasing doses every week.

Side effects

According to the instructions to Akatinol, the drug can cause side effects both on the part of the body as a whole (these can be frequent headaches pain and fatigue), and from its separate systems: respiratory, cardiovascular, digestive and nervous.

Among the side effects should be noted such as:

  • Nausea and vomiting;
  • Pancreatitis;
  • Convulsions;
  • Violation of gait;
  • Dyspnea;
  • Heart failure;
  • Venous thrombosis;
  • Arterial hypertension;
  • Constipation;
  • Dizziness.

According to the instructions to Akatinol, the drug is capable of causing various psychotic reactions, drowsiness, hallucinations and confusion. In rare cases, this remedy can trigger the onset of fungal infections.

special instructions

With simultaneous use, Akatinol may alter the effects of Baclofen or Dantrolene. In this regard, the doses of drugs must be selected individually for each patient.

  • The optimal dose should be achieved gradually, with increasing doses every week.

In individuals with Alzheimer's disease at the stage of severe or moderate dementia, as a rule, the ability to manage complex mechanisms and driving vehicles is impaired. In addition, memantine can affect the reaction rate, so patients undergoing treatment on an outpatient basis, It is necessary to observe the special care at management of mechanisms or driving of motor transport.

Overdose

Overdose of Acatinol Memantine is most often manifested by increased intensity of adverse reactions. In this case, the stomach is washed and activated charcoal is prescribed, and symptomatic therapy is also performed.

Reviews

In the Internet on the drug Akatinol Memantine, you can find both positive and negative feedback. For elderly patients suffering fromAlzheimer's diseaseor other typedementia, this drug often becomes irreplaceable, but, unfortunately, can only slow down the development of the disease and improve the general condition of the patient somewhat. At this time, funds completely rid the person of such ailments, unfortunately, has not yet been invented.

Another frequently discussed side of Acatinol Memantine, despite contraindications in the official instruction, is its administration to children, in order to treat their problemsmental development. In this regard, the reviews about Acatinol Memantine for children are the most diverse, ranging from highly positive and ending sharply negative. There are also frequent evidence of an initially positive effect of the drug on the child followed by a sharp "pullback", returning the small patient to its original state, and sometimes even aggravating it. In any case, the decision to prescribe a drug or medical procedures for children, lies with their leading pediatricians and parents who with full responsibility should approach this issue and work together on the existing problem.

Analogues

Structural analogs for the active substance:

  • Acathinol Memantine;
  • Alzheim;
  • Memanean;
  • Memantal;
  • Memantine Canon;
  • Memantine TL;
  • Memantine hydrochloride;
  • Mémicar;
  • The Memorial;
  • Noogeron.

Before using analogues, consult your doctor.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature of no higher than 25 ° C. Shelf life - 4 years.


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