Remantadine: instructions for use

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width = Remantadine is an antiviral that has an immunomodulatory and antitoxic effect.

The drug reduces the risk of flu, and with its presence promotes rapid recovery. It is also used to prevent tick-borne encephalitis.

The drug was first obtained as a result of chemical synthesis in 1963 on the territory of the United States, and on the territory of the Soviet Union the formula was significantly improved in 1969 - this final version of the drug in question and is now being produced by the pharmacological industry.

Clinical and pharmacological group

Antiviral agent, adamantane derivative.

Terms of sale from pharmacies

You can buy without a doctor's prescription.

Price

How much does Rimantadine in pharmacies? The average price is at the level of100 rubles.

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Composition and form of release

Rimantadine tablets have a white or light yellow color, a circular planocylindrical shape. On one side, a separating risk is applied to conveniently break the tablets in half.

  • Active ingredient: rimantadine hydrochloride - 100 mg in 1 capsule, 50 mg in 1 tablet.
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Additional components of Remantadine capsules:

  • Auxiliary substances: potato starch, stearic acid, lactose monohydrate, dye sunset yellow sunset (Eurolake Sunset Yellow HS (EllO));
  • Composition of the capsule: gelatin, titanium dioxide (E 171).

Auxiliary substances of tablets Remantadine: potato starch, magnesium stearate, microcrystalline cellulose, lactose monohydrate.

pharmachologic effect

Remantadine is a chemotherapeutic drug with antiviral activity, which is a derivative of amantadine and midantane. This medicine is used as an antiparkinsonian agent.

It is active against tick-borne encephalitis virus, as well as influenza A. The drug has an anti-toxic and immunomodulating effect on the human body. Since the prolonged circulation of the drug in the body is provided by its polymeric structure, an extended period half-life makes it possible to prescribe this remedy not only for therapeutic purposes, but also for the prevention of influenza and encephalitis. The use of Remantadine promotes an increase in the functionality of lymphocytes, the production of alpha and gamma interferons, and also the suppression of specific reproduction of viruses at the initial stage. This medication does not allow viral particles to escape from the cells.

Remantadin reduces the risk of flu. In the presence of this ailment, the above medicine promotes a speedy recovery. The most active drug manifests itself in the first 18 hours of poor health. The initial stage of the flu is the main indication for Remantadine. The drug is adsorbed in the gastrointestinal tract 2-4 hours after oral administration. The active ingredient is metabolized in the liver. The half-life of the drug is 25-30 hours.

Indications for use

Remantadin should be taken only as directed by a specialist. Ignoring the doctor's prescription or using it alone can provoke a worsening of pathologies.

for adults:

Adults receive Remantadine in the following conditions:

  • prevention and treatment of influenza caused by the type A virus strain in the early stages of the disease;
  • prevention of tick-borne encephalitis of viral origin.

for children:

Children from the age of 7 prescribe a device for the prevention and treatment of influenza caused by type A virus.

Remantadine is also prescribed as a medicine for the prevention of infection with the encephalitis virus with tick bites.

For children under 7 years of age, the use of the drug is contraindicated.

Contraindications

Tablets are not allowed in the following cases:

  • chronic kidney disease;
  • chronic liver diseases;
  • intolerance of one or more components of the drug;
  • Thyroid gland diseases;
  • pregnancy.

Use tablets with extreme caution and only after the appointment of a doctor to those people who have high blood pressure, there is atherosclerosis or epilepsy. Please note that the use of Remantadine may lead to an exacerbation of chronic diseases. In elderly people, delayed excretion of the drug components may be observed. In a group of people who have liver disease, poisoning can occur.

Intended use for pregnancy and lactation

Remantadin is categorically contraindicated for use at any time of pregnancy and during lactation. There are reasons for this. The drug has side effects associated with pain in the stomach, nausea and vomiting, which can exacerbate toxicosis.

Dosage and route of administration

As indicated in the instructions for use Remantadin should be taken orally after eating: swallow capsules / tablets whole and wash down with water.

When influenza treatment should be started within 1-2 days after the appearance of the first symptoms.

Recommended doses:

  • adults and adolescents older than 14 years: the first day - 100 mg 3 times / day or 300 mg once, 2-3 days - 100 mg 2 times / day, 4-5 days - 100 mg 1 time / day;
  • children 10-14 years: 50 mg 3 times / day;
  • children 7-10 years: 50 mg twice a day.

The total duration of treatment is 5 days.

Elderly, patients with epilepsy and severe hepatic insufficiency, the dose is reduced to 100 mg once a day.

For the prevention of influenza, adults should take 50 mg once a day for 30 days, children over 7 years - 50 mg once a day, up to 15 days depending on the epidemiological situation.

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Side effect

In general, rimantadine is tolerated by patients well, and the occurrence of side effects is extremely rare. But against the background of taking the antiviral drug in question, there may appear:

  • dry mouth, nausea and vomiting;
  • increased gassing;
  • pain in the anatomy of the stomach;
  • dizziness and impaired concentration;
  • a headache of a non-intensive nature and insomnia;
  • nervousness and unmotivated fatigue;
  • a classic allergic reaction - hives, itching.

At occurrence of even one of listed side effects reception rimantadina it is necessary to stop immediately and to consult with the attending physician about the advisability of a further course of admission of the antiviral facilities. Most experts either perform a complete replacement of the drug, or adjust the dosage.

Overdose

If there was a poisoning drug, it is necessary to maintain the functions of vital organs and systems. In the literature, cases of overdose with Remantadine have not been described, but there are reports of poisoning with adamantane derivatives - adamantadine. In this case, hallucinations, excitation, cardiac arrhythmias and death were observed.

If poisoning with Remantidine is accompanied by reactions from the nervous system, it is recommended that physostigmine be treated at a dose of 1-2 mg for adults and, mg for children. If necessary, the introduction of physostigmine can be repeated, but in dosage no more than 2 mg of physostigmine per hour.

special instructions

With caution apply rimantadine in arterial hypertension, epilepsy (including in the anamnesis), atherosclerosis of cerebral vessels.

With the use of rimantadine, an exacerbation of chronic comorbidity may occur. In elderly patients with hypertension, the risk of hemorrhagic stroke increases. With a history of epilepsy and anticonvulsant therapy, the risk of epileptic seizure increases with rimantadine. In such cases, rimantadine is used in a dose up to 100 mg / day simultaneously with anticonvulsant therapy.

With influenza caused by virus B, rimantadine exerts an antitoxic effect.

Prophylactic reception is effective at contacts with the sick, with the spread of infection in closed collectives and at a high risk of the disease during the flu epidemic. Perhaps the emergence of drug-resistant viruses.

Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

  1. With simultaneous application of rimantadine reduces the effectiveness of antiepileptic drugs.
  2. Adsorbents, astringents and enveloping agents reduce the absorption of rimantadine.
  3. Paracetamol and acetylsalicylic acid reduce the Cmax of rimantadine by 11%.
  4. Cimetidine reduces the clearance of rimantadine by 18%.
  5. Means, alkalizing urine (acetazolamide, sodium bicarbonate) enhance its effectiveness (decreased excretion by the kidneys).
  6. Means, acidifying urine (ammonium chloride, ascorbic acid), reduce the effectiveness of rimantadine (due to increased its excretion by the kidneys).

Reviews

We offer you to read reviews of people who used the drug Rimantadine:

  1. Elena. Excellent prevention of influenza, I usually buy them before the January-February epidemic, two years already pah-pah do without hospital. There is a trifle, but the effect is not worse than expensive medicines. There is a true nuance - the belly is blowing from him, however it is still better than getting sick with the flu.
  2. Lana. It helps quickly, but the side effects last for several days: a constant buzzing in your ears as if somewhere far away the substation is working, weakness, in the legs especially, but neither the snot nor the throat hurts).
  3. Victor. A week ago he fell ill (ARVI). The acquaintance advised Rimantadine. Coming to the pharmacy, I was certainly surprised at his cheapness and honestly doubted he would help, but after 2 days of his reception it became much easier for me. Excellent tool

Analogues

Structural analogues for the active substance (also added preparations of a similar antiviral focus):

  • Algiers;
  • Amiksin (a similar effect);
  • Arbidol (a similar effect);
  • Inhavirin (a similar effect);
  • Kagocel (a similar effect);
  • Orvire;
  • Rimantadine;
  • Rimantadine Aktitab;
  • Rimantadine-STI;
  • Rimantadine hydrochloride.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

According to the instructions Remantadin is recommended to store in a dry place, sufficiently protected from the effects of light. Recommended temperature regime - not exceeding room temperature. Shelf life - no more than 5 years.


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