Salofalk candles

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width = Salofalk is an intestinal anti-inflammatory drug that provides a local anti-inflammatory effect associated with the inhibition of neutrophilic lipoxygenase, as well as the synthesis of leukotrienes and prostaglandins.

The active component stops the degranulation, migration, phagocytosis of neutrophils and the process of secretion of immunoglobulins by lymphocytes. There is an antioxidant effect due to the fact that mesalazine is capable of binding to free oxygen radicals and their destruction.

Also, the substance can catch those radicals that are formed from the reactive oxygen compounds.

Clinical and pharmacological group

A drug with anti-inflammatory action, used to treat NNC.

Terms of sale from pharmacies

It is possible to buy under the prescription of the doctor.

Price

How much are Salofalk candles 500mg in pharmacies? The average price is at the level of1 500 rubles.

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Composition and form of release

The drug Salofalk is released in the dosage form of a suppository (suppository) for rectal (into the cavity of the rectum) application. They have a white, cream-colored color, a torpedo shape, small dimensions and a smooth surface.

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  • The composition of suppositories includes the active ingredient mesalazine and solid fat as an auxiliary component.

Rectal suspension contains mesalazine and a number of additional substances: carbomer, xanthan gum, sodium benzoate, sodium ethylaminoacetate, potassium acetate, potassium disulphite, nitrogen gas, water.

pharmachologic effect

The main active component of the candles Salofalk mesalazine has a pronounced anti-inflammatory therapeutic effect, which is realized due to a decrease in the concentration of prostaglandins, leukotrienes and other proinflammatory mediators in the focus of the pathological process. These mediators increase the permeability of the walls of the vessels of the microcirculatory bed with the release of plasma into intercellular substance of tissues and their edema, irritate sensitive nerve endings with painful sensations.

Also, mesalazine has an antioxidant effect, which is realized by binding free radicals, which are fragments of organic molecules that have a pronounced chemical activity and destroy membranes cells.

Indications for use

Medical use of suppositories Salofalk is indicated for the treatment and prevention of exacerbation of ulcerative colitis and Crohn's disease (pathological processes characterized by noninfectious inflammation of the mucous membrane of the colon with the formation of small defects in it in the form ulcers).

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Contraindications

Rectal forms of the drug (enema, Salofalk candles) are not used in such diseases and conditions:

  • serious violations of the liver and kidneys;
  • exacerbation of stomach and duodenum ulcers;
  • hemorrhagic diathesis, in which there is a tendency to bleeding;
  • age of child under 2 years;
  • high sensitivity to the components of the drug.

The drug Salofalk in chronic colitis is cautiously prescribed for violations of respiratory function, kidneys, as well as for lack of glucose-6-phosphate dehydrogenase.

Intended use for pregnancy and lactation

The agent is prescribed in the first trimester of pregnancy only if there are strict indications. In the subsequent months of pregnancy, Salofalk is prescribed if the intended benefit is higher than the probable risk. Doctors recommend, if possible, to stop treatment in the last weeks of pregnancy.

With lactation, prescribe the medicine strictly according to the indications. If diarrhea develops during the treatment of a nursing mother, the therapy should be stopped immediately. At the planning stage of pregnancy, it is recommended to stop therapy or reduce the dosage of the drug.

Dosage and route of administration

Suppositories rectal:

Adults prescribe 1 suppository 500 mg or 2 suppositories 250 mg 3 times / day. In severe forms of the disease, the dose can be doubled.

With long-term maintenance treatment and for the prevention of relapses - 1 suppository 250 mg 3 times / day.

Children with a body weight of up to 40 kg are prescribed a 1/2 day dose for adults - 1 suppository, 250 mg 3 times / day, children with a body weight of more than 40 kg - 1 suppository 500 mg or 2 suppositories 250 mg 3 times / day.

Rectal suspension:

The contents of one vial are administered rectally 1 time / day before bedtime (it is recommended to clean the intestine). The daily dose is 30-50 mg / kg body weight. The maximum daily dose is 3 g.

To prevent relapses, oral intake of Salofalk in the form of tablets in a dose of 15-30 mg / kg of body weight / day is recommended. The daily dose should be divided into 2 divided doses.

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Side effect

Admission Salofalk can cause the following side effects:

  • dizziness, headache, malaise, tinnitus, tremor, depression, convulsions, paresthesia;
  • abdominal pain, nausea, vomiting, diarrhea, flatulence, hepatitis, increased levels of hepatic transaminases;
  • myalgia, arthralgia;
  • tachycardia, chest pain, dyspnea, arterial hypo- or hypertension.

Salofalk can provoke the development of anemia, agranulocytosis, leukopenia, thrombocytopenia, proteinuria, oliguria, anuria, hematuria, crystalluria and hypoprothrombinemia.

Among the possible allergic reactions - itching, fever, skin rash, erythema, pericarditis, bronchospasm and myocarditis. In patients with hypersensitivity to the drug may develop interstitial nephritis, nephrotic syndrome and acute pancreatitis. In some cases, the drug can cause allergic alveolitis and pancolitis, and in some patients, the intake Salofalk and analogues of the drug with a similar chemical structure led to the appearance of symptoms similar to the syndrome of systemic red lupus.

Overdose

In case of a significant excess of the recommended therapeutic dose of suppositories Salofalk appears nausea, drowsiness, general weakness, vomiting. Treatment of overdose is only symptomatic, since there is no specific antidote for the active ingredient of the drug.

special instructions

Before the appointment of the drug, it is necessary to determine the parameters of the functional state of the liver (activity of alanine aminotransferase or aspartate aminotransferase). Further control is recommended to be carried out 2 weeks after the start of treatment, then 2-3 more times during the therapy with 4-week intervals. If the results of the tests are normal, the study can be performed every 3 months, if any symptoms appear - immediately.

Before the beginning of treatment, during, and after the termination of the course, general urine and blood tests should be performed.

When using oral forms of Salofalk, caution should be exercised when performing potentially hazardous activities, incl. when driving vehicles.

When taking tablets and granules, it is possible to stain urine and tears in a yellow-orange color, as well as staining of soft contact lenses.

In case of hospitalization, the patient should inform the doctor about the use of Salofalk.

The foam cylinder is under high pressure, so it can not be heated to more than 50 ° C, expose exposure to sunlight, pierce and open, use near incandescent objects and open fire.

Interaction with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

  1. With the simultaneous use of Salofalk causes an increase in the effect of anticoagulants.
  2. With the simultaneous use of Salofalk enhances the hypoglycemic effect of sulfonylurea derivatives.
  3. With the simultaneous use of Salofalk increases the toxicity of methotrexate.
  4. With the simultaneous use of Salofalk enhances the damaging effect of GCS on the gastric mucosa.
  5. With simultaneous application, Salofalk reduces the tuberculostatic effect of rifampicin.
  6. With simultaneous application, Salofalk reduces the uricosuric effect of probenecid and sulfinpyrazone.
  7. With the simultaneous use of Salofalk reduces the diuretic effect of spironolactone and furosemide.

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Reviews

We offer you to familiarize yourself with the opinions of people who used Salofalk candles:

  1. Victor. With the treatment of diverticulosis of the intestine, this drug has proven itself on the best side, and that it is made in Germany, speaks volumes. Thanks to the professor, who correctly appointed "Salofalk" in the granules of the pharmaceutical company "Doctor Falk he relieved me of the operation that had already been scheduled. The disadvantage is that they are expensive and take more than one year for an individually prescribed method, and in three or four months, of course, will not give a positive result.
  2. Sasha. This is probably the best medicine that can be taken with ulcerative colitis. I always buy them an exacerbation, I have never failed. The price, of course, rather big, but for a European drug this is normal. And it is better to pay more, but do without pobochek and unnecessary problems. Another plus is different forms of release, sometimes just candles or microclystia are enough to relieve the symptoms of an exacerbation and do not take pills and spoil the stomach. And, of course, the main thing is that "Salofalk" is a non-hormonal drug, like many other medicines that our doctors prescribe for autoimmune diseases.

Those users who come to the forum to leave feedback about the Salofalk candles and other forms of this medication often write about the fact that the drug is quite effective. Some patients call it the most effective cure for ulcerative colitis. But, despite the fact how effective is Salofalk, patients' reviews often indicate that the medicine is very expensive, so it is not always available.

Analogues

Analogues Salofalka - a medication Asakol, Mezavant, Kansalazin, Mesakol, Mesalazin, Mezavant, Pentasa, Salozinal and others.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Shelf life of suppositories Salofalk is 3 years from the date of manufacture. The preparation should be stored in the original factory packaging, dark, dry, inaccessible to children at an air temperature of no higher than 25 ° C.


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